Held on November 9-10, 2016, at the
Nasa Ames Research Park, Mountain View, California
The Vascular Tissue Challenge Roadmapping Workshop examined in great detail the state of the art technology in thick-tissue vascularization and 3D tissue engineering. As well as mapping out the pathways, milestones, and challenges towards ending the organ shortage benefiting from these technologies.
The goal of this workshop was to guide future research efforts and encourage new support in bringing about the end-product technologies for patients in need.
The workshop gathered together a diverse network of experts in tissue engineering, microgravity research, and other areas of interest to the advancement of tissue engineering technology. Throughout the two-day workshop, we enjoyed hearing from leading researchers who are working hard to advance this state of the art technology. These subject matter experts also participated in various roundtable discussions to identify the challenges, map out the future pathways, and milestones that would take us to the ultimate solution.
We greatly benefited from the their vast knowledge and expertise during the entire workshop. We are confident that you will too. Please click on the links below to enjoy a few highlights from the Vascular Tissue Challenge Roadmapping Workshop.
Beta Roadmap Report from the December 2014 - July 2015 Roadmapping Process including the the NSF-Funded Washington D.C. Workshop & White House Roundtable.
CHAIR JOSHUA NEUBERT
CHAIR MONSI ROMAN
The Challenges of Vascularizing Engineered Heart Tissue
Wake Forest University's Bioprinting Capabilities
Penn State University, VTC Team Presentation
CHAIR SCOTT COLLINS
Roadmapping Roundtables 2: Overcoming the Challenges
CHAIR SCOTT COLLINS
CHAIR JANA STOUDEMIRE
CHAIR IOANA COZMUTA
CHAIR LINA CONSTANTINOVICI
Lt. Col. Luis Alvarez
Academy Professor & Director, Center for Molecular Science, U.S Military Academy; Founding Principal Investigator, Regenerative Biology Group, National Cancer Institute
Dr. Scott Collins
CTO, TeVido Biodevices
New Organ Alliance, Roadmap Chair
Dr. Ioana Cozmuta
Industry Innovation & Microgravity Lead,
NASA, Space Portal Office
Dr. Wendy Dean
Medical Officer, DoD USAMRMC
VT Challenge, Judging Committee
Mr. David Gobel
CEO, Methuselah Foundation
Dr. Timothy Hammond
Professor, Duke University Veterans Affairs Medical Center
VT Challenge Judging Committee
Mrs. Lynn Harper
Lead for Integrative Studies, NASA Space Portal; NASA Challenge Administrator, VT Challenge.
Dr. Anthony Jeevarajan
Deputy Division Chief, Biomedical Research & Environmental Sciences, NASA JSC
Dr. Armand Keating
Professor, University of Toronto
VT Challenge, Judging Committee
Mr. Joshua Neubert
CEO, Institute of Competition Sciences
Managing Partner, New Organ Alliance
Dr. Maria Rapoza
Executive Director, Duke University
Cardiovascular Research Center
Mrs. Monserrate Roman
Director, NASA Centennial Challenges Program
Dr. Boris Schmalz
Research Associate, Max Planck Institutes
Coordinator, New Organ Alliance
Partner, BVC Fund, Founder, Startup Nectar
Mrs. Jana Stoudemire
Life Sciences Lead, Center for the Advancement of Science in Space
Dr. Keith Murphy
Dr. Michael Roberts
Deputy Chief Scientist, CASIS
Dr. Kevin Healy
University of California, Berkeley
Dr. Yunzhi Yang
Dr. Michele Grimm
Program Manager, NSF BME
Dr. Jedd Lewis
Executive Director, Organ Preservation Alliance
Dr. Melanie Matheu
Founder, Prellis Biologics
Dr. David Fyhrie
UC Davis; NSF BMMB
Dr. Brenda Ogle
University of Minnesota
Dr. Yong Huang
University of Florida
Dr. Ngan Huang
Dr. Joseph Wu
Dr. Todd McDevitt
UCSF, Gladstone Institutes
New Organ's goal is to ensure no one dies from lack of a healthy organ. The New Organ Liver Prize is our first step toward that goal.
Around the world, millions of people need replacement organs, and many die before finding a suitable donor. In the United States, the wait list has skyrocketed while the number of available organs has stayed relatively flat. Even those fortunate enough to find an organ in time face serious medical difficulties, often for the rest of their lives.
The growing field of regenerative medicine offers many potential solutions, but it is drastically underfunded compared to more established areas of medicine. We're developing a challenge prize series to spur innovation in whole organ regeneration, engineering, and preservation and to help draw popular attention to this vital cause.
In order to put regenerative medicine and tissue engineering on the map as game-changing solutions to organ disease and the global organ shortage, we wanted to create a powerful focal point, and prizes are perfect for this.
Well-executed challenge prizes have launched entire industries in the past, such as the Orteig Prize won by Charles Lindbergh in 1927, which transformed U.S. aviation. Among other things, good prizes can attract new capital to seemingly intractable problems, motivate top minds and non-traditional players, galvanize public demand, force regulatory reform, encourage smart risk taking, and help transcend perceived constraints.
Right now, the New Organ Liver Prize is worth $1 million. We are actively seeking partners to increase that amount.
Many, many people have been affected by organ disease and the organ shortage crisis, if not directly, then indirectly through the suffering of friends or family members. What's more, we believe that breakthroughs in whole organ tissue engineering will act as a catalyst for accelerating regenerative technologies as a whole, and regenerative medicine is going to make all of our lives dramatically better. This belief was a key motivator for us in designing the New Organ Liver Prize.
Our initial prize, the New Organ Liver Prize, is the first in a series of challenges and awards to incentivize tissue engineering solutions for all of the complex solid organs, including the heart, kidney, lungs, and pancreas. We're also currently exploring a prize focused on organ preservation with the Organ Preservation Alliance, a coalition incubated by Singularity University Labs.
Absolutely. The New Organ Liver Prize is open to qualified teams wishing to participate from anywhere in the world.
The Methuselah Foundation (New Organ's host charity) does not claim any rights on IP produced by the prize teams.
If you haven't already, sign up as an organ donor. New Organ exists to usher in broader, longer-term solutions to the organ crisis, but donor organ transplants still save tens of thousands of lives every year right now. Take a few minutes to register at donatelife.net.
You can support New Organ directly by donating here, as well as sharing via social media.
No. The full $1 million prize will be awarded to the first registered team that can create a regenerative or bio-engineered solution that enables a large animal to survive 90 days without native liver function.
To register, please submit an Intent to Participate form to the New Organ team at least seven months before beginning trials. Register your team here: https://www.neworgan.competitionsciences.org/prizes/liver-prize/register
Once accepted, teams will later be required to submit a Team Agreement, an Executive Summary, and a series of Team Trial Application documents to the judging committee.
The New Organ Liver Prize will be judged by a panel of five to seven independent, highly-qualified experts. We're in the process of forming the judging committee, which will be solely responsible for evaluating compliance with all prize guidelines and rules, and will have final authority in awarding the prize.
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