Deprecated: get_option was called with an argument that is deprecated since version 5.5.0! The "comment_whitelist" option key has been renamed to "comment_previously_approved". in /home/customer/www/neworgan.competitionsciences.org/public_html/wp-includes/functions.php on line 5144

Deprecated: get_option was called with an argument that is deprecated since version 5.5.0! The "blacklist_keys" option key has been renamed to "disallowed_keys". in /home/customer/www/neworgan.competitionsciences.org/public_html/wp-includes/functions.php on line 5144
Cardiovascular - New Organ Alliance

Cardiovascular
cell sourcing challenges

[breadcrumb]

cardiovascular
sub-challenges

  • Determine whether it’s feasible to cultivate cells from the patient, off the shelf cells from human sources, or xeno-sourced cells.  What are the survivability and stress tolerance standards that cells must meet to be seriously considered as a possibility?
  • Identify methods of scaling up cardiomyocyte production from pluripotent stem cell differentiation. How can we mass produce hiPSC-CMs in a reactor-based format that incorporates self-selection to purify cardiomyocytes during the differentiation process?
  • Identify novel cell surface markers for stem cell-derived cardiomyocytes that can allow for the specific identification, selection, and sorting of cardiomyocytes during the cardiomyocyte differentiation process from stem cells.
  • Identify other support cells that may be important for hiPSC-CM function. Besides hiPSC-CMs and endothelial cells, what is the role of other cell types that should be potentially incorporate (i.e. fibroblasts, pericytes, smooth muscle cells, mesenchymal stem cells)

Join The Conversation

>