Determine whether it’s feasible to cultivate cells from the patient, off the shelf cells from human sources, or xeno-sourced cells. What are the survivability and stress tolerance standards that cells must meet to be seriously considered as a possibility?
Identify methods of scaling up renal epithelial cell production from pluripotent stem cell differentiation. How can we mass-produce diverse renal cell types in a reactor-based format that incorporates self-selection to purify renal cell types during the differentiation process?
Identify novel cell surface markers for stem cell-derived proximal tubular and other cell types that can allow for the specific identification, selection, and sorting of cell types during the renal differentiation process from stem cells.