Identify means by which renal cell types can functionally integrate into host kidney tissue following differentiation from pluripotent stem cells.
Examine means by which stem cell-derived vasculature (endothelial cells) can be used to perfuse host tissues or perfuse new stem cell-derived tissues. Work can be done in the realm to 3D printing to attempt to produce vasculature with lumen-like structures that could carry oxygenated blood to host tissues.
Longer term, but could stem cell-derived cells network cells be developed to form the physiological electrolyte gradients necessary for renal function?
How will innervation of new tissues be stimulated?