Cardiovascular 
VASCULARIZATION CHALLENGE

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cardiovascular
sub-challenges

  • Creation of multiscale and multiphenotype vascular networks in cubic centimeter volumes.
  • Perfusion of engineered vascular networks. Perfusion must also include energy and oxygen rich perfusate.
  • Understand the cross talk between cardiomyocytes and vascular cells, and leverage these interactions to rapidly obtain more comprehensive vascular networks.
  • Understand relationship between cardiomyocyte functional parameters and vasculature:  when and how much vascularization is required for cardiomyocytes conduction and contraction?

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